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Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic

Abstract:
Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPR-mediated somatic cell therapy.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher version

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Publisher copy:
10.1186/s13073-017-0475-4

Authors


Eckstein, L More by this author
More by this author
Institution:
University of Oxford
Department:
Nuffield Department of Population Health; Population Health
Sherkow, JS More by this author
Otlowski, M More by this author
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University of Tasmania More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Genome medicine Journal website
Volume:
9
Issue:
1
Pages:
85
Publication date:
2017-09-25
DOI:
ISSN:
1756-994X
Pubs id:
pubs:732229
URN:
uri:9fc20fe2-3c18-4260-87ac-d1656af2850a
UUID:
uuid:9fc20fe2-3c18-4260-87ac-d1656af2850a
Local pid:
pubs:732229
Language:
English
Keywords:

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