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Journal article

SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells.

Abstract:

Somatostatin-14 (SST) inhibits insulin and glucagon secretion by activating G protein-coupled somatostatin receptors (SSTRs), of which five isoforms exist (SSTR1-5). In mice, the effects on pancreatic β-cells are mediated by SSTR5, whereas α-cells express SSTR2. In both cell types, SSTR activation results in membrane hyperpolarization and suppression of exocytosis. Here, we examined the mechanisms by which SST inhibits secretion from human β- and α-cells and the SSTR isoforms mediating these ...

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Publication status:
Published

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Publisher copy:
10.1152/ajpendo.00207.2012

Authors


van de Bunt, M More by this author
Johnson, PR More by this author
MacDonald, PE More by this author
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Journal:
American journal of physiology. Endocrinology and metabolism
Volume:
303
Issue:
9
Pages:
E1107-E1116
Publication date:
2012-11-05
DOI:
EISSN:
1522-1555
ISSN:
0193-1849
URN:
uuid:9fb6f6d5-d209-4fc2-b122-5052a13b6438
Source identifiers:
349784
Local pid:
pubs:349784

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