Edit, cut and paste in the nicotinic acetylcholine receptor gene family of Drosophila melanogaster.

Journal article

Nicotinic acetylcholine receptors (nAChRs) are important for fast synaptic cholinergic transmission. They are targets of drugs/chemicals for human and animal health as well as for pest control. With the advent of genome sequencing, entire nAChR gene families have now been described for vertebrates and invertebrates. Mostly, these are extensive with a large number of distinct subunits, making possible many nAChR subtypes differing in transmitter affinity, channel conductance, ion selectivity, ...

Expand abstract

Authors: Sattelle, D; Jones, A; Sattelle, B; Matsuda, K; Reenan, R

• Publication status: Published
• Journal: BioEssays : news and reviews in molecular, cellular and developmental biology
• Volume: 27
• Issue: 4
• Pages: 366-376
• Publication date: 2005-04-01
• DOI: 10.1002/bies.20207
• EISSN: 1521-1878
• ISSN: 0265-9247
• Language: English
• Keywords: Receptors, Nicotinic; Humans; Drosophila melanogaster; Amino Acid Sequence; RNA Processing, Post-Transcriptional; Nitro Compounds; Protein Conformation; Imidazoles; Sequence Alignment; RNA Editing; Molecular Sequence Data; Alternative Splicing; Binding Sites; Protein Isoforms; Models, Molecular; Multigene Family; Protein Subunits; Cholinergic Agents; Animals; Insecticides