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Cohesin-Mediated Genome Architecture Does Not Define DNA Replication Timing Domains

Abstract:

3D genome organization is strongly predictive of DNA replication timing in mammalian cells. This work tested the extent to which loop-based genome architecture acts as a regulatory unit of replication timing by using an auxin-inducible system for acute cohesin ablation. Cohesin ablation in a population of cells in asynchronous culture was shown not to disrupt patterns of replication timing as assayed by replication sequencing (RepliSeq) or BrdU-focus microscopy. Furthermore, cohesin ablation ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.3390/genes10030196

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Oxford college:
University, University College
Nieduszynski, CA More by this author
Publisher:
MPDI Open Access Journals Publisher's website
Journal:
Genes Journal website
Volume:
10
Issue:
3
Pages:
Article: 196
Publication date:
2019-03-04
Acceptance date:
2019-02-19
DOI:
ISSN:
2073-4425
Pubs id:
pubs:983100
URN:
uri:9facaa86-a5be-407f-a542-a734a5ff4ece
UUID:
uuid:9facaa86-a5be-407f-a542-a734a5ff4ece
Local pid:
pubs:983100

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