Journal article
Cohesin-Mediated Genome Architecture Does Not Define DNA Replication Timing Domains
- Abstract:
-
3D genome organization is strongly predictive of DNA replication timing in mammalian cells. This work tested the extent to which loop-based genome architecture acts as a regulatory unit of replication timing by using an auxin-inducible system for acute cohesin ablation. Cohesin ablation in a population of cells in asynchronous culture was shown not to disrupt patterns of replication timing as assayed by replication sequencing (RepliSeq) or BrdU-focus microscopy. Furthermore, cohesin ablation ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
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- Files:
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(pdf, 3.9MB)
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- Publisher copy:
- 10.3390/genes10030196
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Authors
Bibliographic Details
- Publisher:
- MPDI Open Access Journals Publisher's website
- Journal:
- Genes Journal website
- Volume:
- 10
- Issue:
- 3
- Pages:
- Article: 196
- Publication date:
- 2019-03-04
- Acceptance date:
- 2019-02-19
- DOI:
- ISSN:
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2073-4425
- Pubs id:
-
pubs:983100
- URN:
-
uri:9facaa86-a5be-407f-a542-a734a5ff4ece
- UUID:
-
uuid:9facaa86-a5be-407f-a542-a734a5ff4ece
- Local pid:
- pubs:983100
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright holder:
- Oldach and Nieduszynski
- Copyright date:
- 2019
- Notes:
- © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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