Journal article
Ligand binding to a G protein-coupled receptor captured in a mass spectrometer.
- Abstract:
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G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptors belong to the largest family of membrane-embedded cell surface proteins and are involved in a diverse array of physiological processes. Despite progress in the mass spectrometry of membrane protein complexes, G protein-coupled receptors have remained intractable because of their low yield and instability after extraction from cell membranes. We established conditions in the mass spectrometer that preserve noncoval...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 903.1KB, Terms of use)
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- Publisher copy:
- 10.1126/sciadv.1701016
Authors
Funding
Bibliographic Details
- Publisher:
- American Association for the Advancement of Science
- Journal:
- Science Advances More from this journal
- Volume:
- 3
- Issue:
- 6
- Pages:
- e1701016
- Publication date:
- 2017-06-01
- Acceptance date:
- 2017-04-27
- DOI:
- EISSN:
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2375-2548
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:701827
- UUID:
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uuid:9fac0b85-5032-4a8c-b58b-74424c2b0239
- Local pid:
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pubs:701827
- Source identifiers:
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701827
- Deposit date:
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2017-07-12
Terms of use
- Copyright holder:
- Allison et al
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
- Licence:
- CC Attribution (CC BY)
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