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Increased slow wave sleep with 5-HT2 receptor antagonists: detection by ambulatory EEG recording and automatic sleep stage analysis.

Abstract:

The effect on slow wave sleep (SWS) of 5-HT antagonists with different affinities for 5-HT(1) and 5-HT(2) receptors was investigated using ambulatory EEG monitoring in normal volunteers. The selective 5-HT( 2) antagonists, ritanserin and cypropheptadine, increased SWS while the non-selective 5-HT antagonist metergoline did not. The histamine H( 1)-receptor antagonist, mepyramine, was similarly without effect on SWS. These findings suggest that home ambulatory monitoring with automatic sleep s...

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Publisher copy:
10.1177/026988118900300301

Authors


Journal:
Journal of psychopharmacology (Oxford, England)
Volume:
3
Issue:
3
Pages:
125-129
Publication date:
1989-01-05
DOI:
EISSN:
1461-7285
ISSN:
0269-8811
URN:
uuid:9fa98771-11e8-4288-a5a2-c30e0d850519
Source identifiers:
186079
Local pid:
pubs:186079
Language:
English

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