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High aldehyde dehydrogenase activity identifies tumor-initiating and metastasis-initiating cells in human prostate cancer.

Abstract:

Metastatic progression of advanced prostate cancer is a major clinical problem. Identifying the cell(s) of origin in prostate cancer and its distant metastases may permit the development of more effective treatment and preventive therapies. In this study, aldehyde dehydrogenase (ALDH) activity was used as a basis to isolate and compare subpopulations of primary human prostate cancer cells and cell lines. ALDH-high prostate cancer cells displayed strongly elevated clonogenicity and migratory b...

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Publication status:
Published

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Journal:
Cancer research
Volume:
70
Issue:
12
Pages:
5163-5173
Publication date:
2010-06-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:9fa77dd0-a93c-4032-ba28-131475ce9260
Source identifiers:
120689
Local pid:
pubs:120689

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