Journal article
Two bistable switches govern M phase entry
- Abstract:
-
The abrupt and irreversible transition from interphase to M phase is essential to separate DNA replication from chromosome segregation. This transition requires the switch-like phosphorylation of hundreds of proteins by the cyclin-dependent kinase 1 (Cdk1):cyclin B (CycB) complex. Previous studies have ascribed these switch-like phosphorylations to the auto-activation of Cdk1:CycB through the removal of inhibitory phosphorylations on Cdk1-Tyr15 [1, 2]. The positive feedback in Cdk1 activation...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 3.7MB, Terms of use)
-
- Publisher copy:
- 10.1016/j.cub.2016.10.022
Authors
Funding
+ Biotechnology and Biological Sciences Research Council
More from this funder
Funding agency for:
Novák, B
Grant:
Strategic LoLa grant (BB/MM00354X/1
+ Engineering and Physical Sciences Research Council
More from this funder
Funding agency for:
Rata, S
Grant:
EP/G03706X/1
Bibliographic Details
- Publisher:
- Cell Press
- Journal:
- Current Biology More from this journal
- Volume:
- 26
- Issue:
- 24
- Pages:
- 3361-3367
- Publication date:
- 2016-11-15
- Acceptance date:
- 2016-10-12
- DOI:
- ISSN:
-
1879-0445
Item Description
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:663701
- UUID:
-
uuid:9f9daa4b-a021-45ab-8d28-91be0e6bd009
- Local pid:
-
pubs:663701
- Source identifiers:
-
663701
- Deposit date:
-
2016-12-09
Terms of use
- Copyright holder:
- Mochida et al
- Copyright date:
- 2016
- Notes:
-
Copyright © 2016 The Authors. Published by Elsevier Ltd. 3361
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record