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Journal article

CD4 T cells can reject major histocompatibility complex class I-incompatible skin grafts.

Abstract:

We have re-investigated the roles of CD4 and CD8 T cell subsets in skin graft rejection across a single class I MHC disparity. Recipient mice were transplanted with skin from donors transgenic for the class I MHC molecule Kb. As expected, CD8 T cells were sufficient for rapid injection; but surprisingly, CD4 T cells were also competent to do the same. Rejection was dependent on one or the other subset, since elimination of both resulted in indefinite graft survival. The possibility that alloa...

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Publication status:
Published

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Journal:
European journal of immunology
Volume:
29
Issue:
1
Pages:
156-167
Publication date:
1999-01-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:9f8cc125-6175-4284-bb18-7b3485ef173a
Source identifiers:
17310
Local pid:
pubs:17310

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