Journal article
Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism.
- Abstract:
-
Interconversion between cortisone and the glucocorticoid receptor ligand cortisol is carried out by 11beta-hydroxysteroid dehydrogenase (11beta-HSD)isozymes and constitutes a medically important example of pre-receptor control of steroid hormones. The enzyme 11beta-HSD type 1 (11beta-HSD1) catalyzes the conversion of cortisone to its active receptor-binding derivative cortisol, whereas 11beta-HSD type 2 performs the reverse reaction. Specific inhibitors against the type 1 enzyme lower intrace...
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- Publication status:
- Published
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- Publisher copy:
- 10.1007/s00018-003-3476-y
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Bibliographic Details
- Journal:
- Cellular and molecular life sciences : CMLS
- Volume:
- 61
- Issue:
- 7-8
- Pages:
- 992-999
- Publication date:
- 2004-04-01
- DOI:
- EISSN:
-
1420-9071
- ISSN:
-
1420-682X
- Source identifiers:
-
108696
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:108696
- UUID:
-
uuid:9f89b4aa-1cb4-4f3c-a454-d39cf9ec1145
- Local pid:
- pubs:108696
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2004
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