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Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism.

Abstract:

Interconversion between cortisone and the glucocorticoid receptor ligand cortisol is carried out by 11beta-hydroxysteroid dehydrogenase (11beta-HSD)isozymes and constitutes a medically important example of pre-receptor control of steroid hormones. The enzyme 11beta-HSD type 1 (11beta-HSD1) catalyzes the conversion of cortisone to its active receptor-binding derivative cortisol, whereas 11beta-HSD type 2 performs the reverse reaction. Specific inhibitors against the type 1 enzyme lower intrace...

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Publication status:
Published

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Publisher copy:
10.1007/s00018-003-3476-y

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Journal:
Cellular and molecular life sciences : CMLS
Volume:
61
Issue:
7-8
Pages:
992-999
Publication date:
2004-04-05
DOI:
EISSN:
1420-9071
ISSN:
1420-682X
URN:
uuid:9f89b4aa-1cb4-4f3c-a454-d39cf9ec1145
Source identifiers:
108696
Local pid:
pubs:108696

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