- Abstract:
-
Experimental vaccine antigens based upon the HIV-1 envelope glycoproteins (Env) have failed to induce neutralizing antibodies (NAbs) against the majority of circulating viral strains as a result of antibody evasion mechanisms, including amino acid variability and conformational instability. A potential vaccine design strategy is to stabilize Env, thereby focusing antibody responses on constitutively exposed, conserved surfaces, such as the CD4 binding site (CD4bs). Here, we show that a largel...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/jvi.01161-13
-
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- Journal:
- Journal of virology
- Volume:
- 87
- Issue:
- 18
- Pages:
- 10163-10172
- Publication date:
- 2013-09-05
- DOI:
- EISSN:
-
1098-5514
- ISSN:
-
0022-538X
- URN:
-
uuid:9f80b32c-a730-4009-906a-4d0c7e2c343e
- Source identifiers:
-
410992
- Local pid:
- pubs:410992
- Copyright date:
- 2013
Journal article
Immune focusing and enhanced neutralization induced by HIV-1 gp140 chemical cross-linking.
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