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Combined single-molecule force and fluorescence measurements for biology.

Abstract:
Recent advances in single-molecule techniques allow the application of force to an individual biomolecule whilst simultaneously monitoring its response using fluorescent probes. The effects of applied mechanical load on single-enzyme turnovers, biomolecular interactions and conformational changes can now be studied with nanometer precision and millisecond time resolution.

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Publisher copy:
10.1186/1475-4924-2-4

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
Molloy, JE More by this author
Trentham, DR More by this author
Journal:
Journal of biology
Volume:
2
Issue:
1
Pages:
4
Publication date:
2003
DOI:
EISSN:
1475-4924
ISSN:
1478-5854
URN:
uuid:9f7c2b47-dc4e-449b-959f-2f2cf209c7b3
Source identifiers:
59561
Local pid:
pubs:59561

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