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Small RNA-Mediated Epigenetic Myostatin Silencing.

Abstract:

Myostatin (Mstn) is a secreted growth factor that negatively regulates muscle mass and is therefore a potential pharmacological target for the treatment of muscle wasting disorders such as Duchenne muscular dystrophy. Here we describe a novel Mstn blockade approach in which small interfering RNAs (siRNAs) complementary to a promoter-associated transcript induce transcriptional gene silencing (TGS) in two differentiated mouse muscle cell lines. Silencing is sensitive to treatment with the hist...

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Publication status:
Published

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Publisher copy:
10.1038/mtna.2012.15

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Molecular therapy. Nucleic acids
Volume:
1
Issue:
5
Pages:
e23
Publication date:
2012-01-05
DOI:
EISSN:
2162-2531
ISSN:
2162-2531
URN:
uuid:9f6cdfa8-e3fe-4c10-b113-696a09f1f08f
Source identifiers:
364428
Local pid:
pubs:364428
Language:
English

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