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Structural characterisation of the bromouracil.guanine base pair mismatch in a Z-DNA fragment.

Abstract:

The deoxyoligonucleotide d(BrU-G-C-G-C-G) was crystallised at pH 8.2 and its structure analysed by X-ray diffraction. The unit cell, of dimensions a = 17.94, b = 30.85, c = 49.94A contains four DNA duplexes in space group P2(1)2(1)2(1). The duplexes are in the Z conformation, with four Watson-Crick G.C base pairs and two BrU.G base pairs. The structure was refined to an R factor of 0.16 at a resolution of 2.2A with 64 solvent molecules located. The BrU.G base pair mismatch is of the wobble ty...

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Publication status:
Published

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Publisher copy:
10.1093/nar/14.4.1801

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Hunter, WN More by this author
Kennard, O More by this author
Journal:
Nucleic acids research
Volume:
14
Issue:
4
Pages:
1801-1809
Publication date:
1986-02-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:9f69c0e3-a58c-414c-9ae5-f3034f776ffd
Source identifiers:
400334
Local pid:
pubs:400334

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