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Gestational diabetic transcriptomic profiling of microdissected human trophoblast

Abstract:

Gestational diabetes mellitus (GDM), the most common metabolic complication of pregnancy, is influenced by the placenta, and its prevalence directly increases with obesity. Therefore, to define the aetiology of GDM requires that the confounding influence of obesity and the heterogeneous nature of the placenta impairing accurate quantitative studies be accounted for. Using laser capture microdissection (LCM), we optimized RNA extraction from human placental trophoblast, the metabolic cellular ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1530/JOE-15-0424

Authors


Bastie, CC More by this author
Sheppard, AM More by this author
More by this author
Department:
Oxford, MSD, Obstetrics & Gynaecology
Publisher:
BioScientifica Publisher's website
Journal:
Journal of Endocrinology Journal website
Volume:
229
Pages:
47-59
Publication date:
2016-04-01
Acceptance date:
2016-02-11
DOI:
ISSN:
0022-0795 and 1479-6805
Pubs id:
pubs:606220
URN:
uri:9f693f1a-71e5-4c49-bef1-03b2ac2bc027
UUID:
uuid:9f693f1a-71e5-4c49-bef1-03b2ac2bc027
Local pid:
pubs:606220

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