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The beta-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner.

Abstract:

We have introduced a human beta-globin minilocus, containing the recently described dominant control region (DCR), the beta-globin or Thy-1 gene, and a thymidine kinase (tk)-neoR gene into erythroid and non-erythroid cells. Analysis of the transcription levels of the genes shows that the DCR directs high levels of human beta-globin, Thy-1 and tk-neo expression independent of integration sites in an erythroid-specific manner. The presence of the DNAasel hypersensitive sites at the 5' end of th...

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Publication status:
Published

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Authors


Blom van Assendelft, G More by this author
Hanscombe, O More by this author
Grosveld, F More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School, BHF Centre of Research Excellence
Journal:
Cell
Volume:
56
Issue:
6
Pages:
969-977
Publication date:
1989-03-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:9f678ad6-edfc-4970-8948-8649815f8780
Source identifiers:
8403
Local pid:
pubs:8403

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