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Journal article

State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1.

Abstract:

We previously reported that TREK-1 gating by internal pH and pressure occurs close to or within the selectivity filter. These conclusions were based upon kinetic measurements of high-affinity block by quaternary ammonium (QA) ions that appeared to exhibit state-independent accessibility to their binding site within the pore. Intriguingly, recent crystal structures of two related K2P potassium channels were also both found to be open at the helix bundle crossing. However, this did not exclude ...

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Publication status:
Published

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Publisher copy:
10.4161/chan.22153

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Journal:
Channels (Austin, Tex.)
Volume:
6
Issue:
6
Pages:
473-478
Publication date:
2012-01-01
DOI:
EISSN:
1933-6969
ISSN:
1933-6950
URN:
uuid:9f65f61e-1fe5-4f25-9974-bfac97e18d8f
Source identifiers:
352588
Local pid:
pubs:352588

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