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Journal article

Direct versatile route to conformationally constrained glutamate analogues

Abstract:
Novel conformationally constrained glutamate analogues are readily available from (S)-pyroglutamic acid; using a bicyclic lactam template, diastereocontrolled and sequential modification of the pyrrolidine ring is possible, allowing a versatile access to several glutamate and kainoid analogues; variations in the C(2)H-C(3)H coupling constants were observed depending upon the nature of remote substituents on the heterocyclic ring, consistent with modification of the ring conformation.
Publication status:
Published

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Publisher copy:
10.1039/a708429c

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
CHEMICAL COMMUNICATIONS
Issue:
4
Pages:
461-462
Publication date:
1998-02-21
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
URN:
uuid:9f638452-5fb7-4cc0-bda2-d6540ef52933
Source identifiers:
36429
Local pid:
pubs:36429
Language:
English

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