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Global microRNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes.

Abstract:

AIMS/HYPOTHESIS: MicroRNAs regulate a broad range of biological mechanisms. To investigate the relationship between microRNA expression and type 2 diabetes, we compared global microRNA expression in insulin target tissues from three inbred rat strains that differ in diabetes susceptibility. METHODS: Using microarrays, we measured the expression of 283 microRNAs in adipose, liver and muscle tissue from hyperglycaemic (Goto-Kakizaki), intermediate glycaemic (Wistar Kyoto) and normoglycaemic (B...

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Publication status:
Published

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Publisher copy:
10.1007/s00125-010-1667-2

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Journal:
Diabetologia
Volume:
53
Issue:
6
Pages:
1099-1109
Publication date:
2010-06-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:9f631646-7e51-451e-9beb-021cc94cb6f4
Source identifiers:
50297
Local pid:
pubs:50297

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