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Journal article

Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q.

Abstract:

OBJECTIVES: To determine by genetic association analysis whether the 4q functional candidate genes IGFBP7, ADAMTS3, and IL8 might encode for susceptibility to osteoarthritis (OA). METHODS: Expression of IGFBP7, ADAMTS3, and IL8 in adult OA articular cartilage chondrocytes was demonstrated by reverse transcription-polymerase chain reaction. The genes were screened for common polymorphic DNA variants by direct sequencing of exons, intron-exon boundaries, and the 5' and 3' untranslated regions. ...

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Publication status:
Published

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Publisher copy:
10.1136/ard.2004.027342

Authors


Kawahara, C More by this author
Forster, T More by this author
Chapman, K More by this author
Loughlin, J More by this author
Journal:
Annals of the rheumatic diseases
Volume:
64
Issue:
3
Pages:
474-476
Publication date:
2005-03-05
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
URN:
uuid:9f5a898f-8da1-48e6-8c13-0e66d83a8337
Source identifiers:
107295
Local pid:
pubs:107295

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