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Meta-analysis combining parallel and cross-over clinical trials. II: Binary outcomes.

Abstract:

We examine different methods to pool binary outcomes used both in parallel and cross-over trials. Odds ratio (OR) estimators obtained from joint conditional probabilities in cross-over trials, such as the Mantel-Haenszel and Peto methods, are compared to an OR estimator using marginal results of cross-over trials. When there is correlation between the outcomes in the two cross-over periods, joint conditional ORs differ from marginal ORs and cannot be combined with OR estimates from parallel t...

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Publication status:
Published

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Publisher copy:
10.1002/sim.1206

Authors


Elbourne, D More by this author
Altman, DG More by this author
Journal:
Statistics in medicine
Volume:
21
Issue:
15
Pages:
2145-2159
Publication date:
2002-08-05
DOI:
EISSN:
1097-0258
ISSN:
0277-6715
URN:
uuid:9f3cce01-0219-4316-958b-b4a6cb61f40e
Source identifiers:
317927
Local pid:
pubs:317927

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