- Abstract:
-
Class I phosphoinositide-3-kinase (PI3K) isoforms generate the intracellular signaling lipid, phosphatidylinositol(3,4,5)trisphosphate (PtdIns(3,4,5)P 3). PtdIns(3,4,5)P 3 regulates major aspects of cellular behavior, and the use of both genetic and pharmacological intervention has revealed important isoform-specific roles for PI3Ks in health and disease. Despite this interest, current methods for measuring PtdIns(3,4,5)P3 have major limitations, including insensitivity, reliance on radiolabe...
Expand abstract - Publisher copy:
- 10.1038/nmeth.1564
-
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- Journal:
- Nature Methods
- Volume:
- 8
- Issue:
- 3
- Pages:
- 267-272
- Publication date:
- 2011-03-05
- DOI:
- EISSN:
-
1549-1676
- ISSN:
-
1548-7091
- URN:
-
uuid:9f320e74-c177-4f32-9718-e0c77f024ace
- Source identifiers:
-
127389
- Local pid:
- pubs:127389
- Language:
- English
- Copyright date:
- 2011
Journal article
Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry
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