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Comparative 'omics analyses differentiate Mycobacterium tuberculosis and Mycobacterium bovis and reveal distinct macrophage responses to infection with the human and bovine tubercle bacilli

Abstract:

Members of the Mycobacterium tuberculosis complex (MTBC) are the causative agents of tuberculosis in a range of mammals, including humans. A key feature of MTBC pathogens is their high degree of genetic identity yet distinct host tropism. Notably, while Mycobacterium bovis is highly virulent and pathogenic for cattle, the human pathogen M. tuberculosis is attenuated in cattle. Previous research also suggests that host preference amongst MTBC members has a basis in host innate immune responses...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1099/mgen.0.000163

Authors


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ORCID:
0000-0002-3974-0810
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
ORCID:
0000-0003-3899-3872
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ORCID:
0000-0002-2613-0714
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Grant:
SFI Investigator Award 08/IN.1/B2038
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Grant:
H2020 programme grant number 643381 (TBVAC2020)
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Grant:
PhD award 097429/Z/11/Z (K. R-A.)
Publisher:
Microbiology Society Publisher's website
Journal:
Microbial Genomics Journal website
Volume:
4
Issue:
3
Publication date:
2018-03-20
Acceptance date:
2018-02-26
DOI:
EISSN:
2057-5858
Pubs id:
pubs:942201
URN:
uri:9f0794df-0f77-458c-ab73-5613e43f912c
UUID:
uuid:9f0794df-0f77-458c-ab73-5613e43f912c
Local pid:
pubs:942201

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