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Use of electrospray mass spectrometry to directly observe an acyl enzyme intermediate in beta-lactamase catalysis.

Abstract:
Electrospray mass spectrometry was used to directly observe intact acyl enzyme complexes formed between a class C beta-lactamase (from Enterobacter cloacae P99) and four poor substrates/inhibitors. In each case the molecular weight difference between the unreacted and the reacted beta-lactamase was consistent with the formation of an acyl enzyme.
Publication status:
Published

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Authors


Baldwin, JE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
FEBS letters
Volume:
277
Issue:
1-2
Pages:
212-214
Publication date:
1990-12-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:9f05958e-54c8-4572-876b-a9795bb2ca6c
Source identifiers:
35122
Local pid:
pubs:35122

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