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A peptide derived from acetylcholinesterase induces neuronal cell death: characterisation of possible mechanisms.

Abstract:

Acetylcholinesterase (AChE) exhibits functions unrelated to the catalysis of acetylcholine (ACh) in particular during development. Although the underlying mechanism(s) is presently unknown, a candidate peptide fragment (AChE-peptide) has recently been identified, and been shown to induce a continuum of apoptotic and necrotic neuronal cell death in rat hippocampal organotypic cultures. The aim of this study was to trace the cell death pathway initiated by AChE-peptide. Using specific antagonis...

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Publication status:
Published

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Publisher copy:
10.1007/s00221-003-1567-5

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
Experimental brain research
Volume:
153
Issue:
3
Pages:
334-342
Publication date:
2003-12-05
DOI:
EISSN:
1432-1106
ISSN:
0014-4819
URN:
uuid:9efa9432-1835-4442-ae0e-77e93086c15d
Source identifiers:
185246
Local pid:
pubs:185246

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