Journal article
Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145).
- Abstract:
-
Articular cartilage enables weight bearing and near friction-free movement in the joints. Critical to its function is the production of a specialized, mechanocompetent extracellular matrix controlled by master regulator transcription factor SOX9. Mutations in SOX9 cause campomelic dysplasia, a haploinsufficiency disorder resulting in severe skeletal defects and dwarfism. Although much is understood about how SOX9 regulates cartilage matrix synthesis and hence joint function, how this master r...
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- Publication status:
- Published
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- Publisher copy:
- 10.1074/jbc.m111.302430
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Bibliographic Details
- Journal:
- Journal of biological chemistry
- Volume:
- 287
- Issue:
- 2
- Pages:
- 916-924
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Source identifiers:
-
227139
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:227139
- UUID:
-
uuid:9ef91dc5-03ea-4035-9e85-b4f9af6d2204
- Local pid:
- pubs:227139
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2012
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