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Journal article

Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145).

Abstract:

Articular cartilage enables weight bearing and near friction-free movement in the joints. Critical to its function is the production of a specialized, mechanocompetent extracellular matrix controlled by master regulator transcription factor SOX9. Mutations in SOX9 cause campomelic dysplasia, a haploinsufficiency disorder resulting in severe skeletal defects and dwarfism. Although much is understood about how SOX9 regulates cartilage matrix synthesis and hence joint function, how this master r...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m111.302430

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
The Journal of biological chemistry
Volume:
287
Issue:
2
Pages:
916-924
Publication date:
2012-01-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:9ef91dc5-03ea-4035-9e85-b4f9af6d2204
Source identifiers:
227139
Local pid:
pubs:227139

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