Becalming type 17 inflammation in ulcerative colitis

Journal article

Genome-wide association studies in ulcerative colitis point to a role for FcγRIIA, a receptor for IgG. Castro-Dopico et al. (2019) find a profound induction of anti-commensal IgG in the colonic mucosa of UC patients and outline a pathway whereby FcγR activation by IgG triggers IL-1β production, type 17 immunity, and the exacerbation of inflammation.

Authors: Chen, H; Simmons, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: Immunity
• Volume: 50
• Issue: 4
• Pages: 1029-1031
• Publication date: 2019-04-16
• Acceptance date: 2019-03-21
• DOI: 10.1016/j.immuni.2019.03.019
• EISSN: 1097-4180
• ISSN: 1074-7613
• Pmid: 30995495
• Language: English
• Keywords: FFR