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Conservation, extensive heterozygosity, and convergence of signaling potential all indicate a critical role for KIR3DL3 in higher primates

Abstract:

Natural killer (NK) cell functions are modulated by polymorphic killer cell immunoglobulin-like receptors (KIR). Among 13 human KIR genes, which vary by presence and copy number, KIR3DL3 is ubiquitously present in every individual across diverse populations. No ligand or function is known for KIR3DL3, but limited knowledge of expression suggests involvement in reproduction, likely during placentation. With 157 human alleles, KIR3DL3 is also highly polymorphic and we show heterozygosity exceed...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.3389/fimmu.2019.00024

Authors


Leaton, LA More by this author
Kichula, KM More by this author
Nemat-Gorgani, N More by this author
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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
10
Pages:
Article: 24
Publication date:
2019-01-28
Acceptance date:
2019-01-07
DOI:
EISSN:
1664-3224
Pubs id:
pubs:975893
URN:
uri:9ef7e9f7-5aae-46b8-a701-159ea7087cd1
UUID:
uuid:9ef7e9f7-5aae-46b8-a701-159ea7087cd1
Local pid:
pubs:975893

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