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The Mub1/Ubr2 ubiquitin ligase complex regulates the conserved Dsn1 kinetochore protein

Abstract:

The kinetochore is the macromolecular complex that assembles onto centromeric DNA and orchestrates the segregation of duplicated chromosomes. More than 60 components make up the budding yeast kinetochore, including inner kinetochore proteins that bind to centromeric chromatin and outer proteins that directly interact with microtubules. However, little is known about how these components assemble into a functional kinetochore and whether there are quality control mechanisms that monitor kineto...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.pgen.1003216

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Nelson, CR More by this author
Ranish, JA More by this author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
9
Issue:
2
Pages:
e1003216
Publication date:
2013-02-07
Acceptance date:
2012-11-19
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:9ee8867a-e3e8-4008-b7e0-ac409c4fc22c
Source identifiers:
384222
Local pid:
pubs:384222

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