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The effects of a low extracellular concentration of potassium on the activity and numbers of Na+/K+ pumps in an EB-virus transformed human lymphocyte cell line.

Abstract:

The BM1A EB-virus transformed human lymphocyte cell line contains approximately 950,000 Na+/K(+)-ATPase sites per cell. The turnover number of each site is approx. 2240 molecules of rubidium per min. When cells are exposed to a low extracellular concentration of potassium the intracellular concentration of sodium rises, and the cells respond in the short term by increasing the Vmax of 86Rb+ uptake. In the longer term the cells respond by increasing both the Vmax of 86Rb+ uptake and the Bmax o...

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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-Seniors
Role:
Author
Journal:
Biochimica et biophysica acta
Volume:
1027
Issue:
3
Pages:
218-224
Publication date:
1990-09-05
DOI:
ISSN:
0006-3002
URN:
uuid:9ee71dca-06b1-4fc0-ab04-d65ca7be6640
Source identifiers:
322055
Local pid:
pubs:322055

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