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Journal article

A novel checkpoint mechanism regulating the G1/S transition.

Abstract:

Ultraviolet irradiation of fission yeast cells in G1 phase induced a delay in chromatin binding of replication initiation factors and, consistently, a transient delay in S-phase entry. The cell cycle delay was totally dependent on the Gcn2 kinase, a sensor of the nutritional status, and was accompanied by phosphorylation of the translation initiation factor eIF2alpha and by a general depression of translation. However, the G1-specific synthesis of factors required for DNA replication was not ...

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Publication status:
Published

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Publisher copy:
10.1101/gad.421807

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Journal:
Genes and development
Volume:
21
Issue:
6
Pages:
649-654
Publication date:
2007-03-05
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
URN:
uuid:9ee2d0f9-fd0c-46b0-b426-9b643f6e8667
Source identifiers:
209293
Local pid:
pubs:209293

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