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Evolution of HIV-1 within untreated individuals and at the population scale in Uganda

Abstract:

HIV-1 undergoes multiple rounds of error-prone replication between transmission events, resulting in diverse viral populations within and among individuals. In addition, the virus experiences different selective pressures at multiple levels: during the course of infection, at transmission, and among individuals. Disentangling how these evolutionary forces shape the evolution of the virus at the population scale is important for understanding pathogenesis, how drug- and immune-escape variants ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.ppat.1007167

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Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine; Big Data Institute
Role:
Author
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Institution:
University of Oxford
Division:
Maths, Physical & Life Sciences
Department:
Statistics
Role:
Author
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Funding agency for:
Raghwani, J
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Funding agency for:
Raghwani, J
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Funding agency for:
Lythgoe, KA
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Funding agency for:
Lythgoe, KA
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Publisher:
Public Library of Science (PLoS) Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
14
Issue:
7
Chapter number:
e1007167
Publication date:
2018-07-27
Acceptance date:
2018-06-20
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pubs id:
pubs:859453
URN:
uri:9edffa3b-5a87-47e5-9139-fa2ebba6bf49
UUID:
uuid:9edffa3b-5a87-47e5-9139-fa2ebba6bf49
Local pid:
pubs:859453

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