Successful in vivo immunolocalization of Langerhans cell histiocytosis with use of a monoclonal antibody, NA1/34.

Journal article

The antibody NA1/34 is a murine monoclonal antibody directed against the CD1a surface antigen expressed on normal Langerhans cells, cortical thymocytes, and on lesional cells in Langerhans cell histiocytosis (LCH). Our hypothesis was that NA1/34 would localize sites of disease activity in patients with multisystem LCH. To test this hypothesis, indium 111-labeled NA1/34 was administered to five patients with multisystem LCH and serial gamma scans were obtained for up to 120 hours. Serial serum...

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Authors: Kelly, K; Beverley, P; Chu, A; Davenport, V; Gordon, I

• Journal: Journal of pediatrics
• Volume: 125
• Issue: 5 Pt 1
• Pages: 717-722
• Publication date: 1994-11-01
• DOI: 10.1016/s0022-3476(94)70063-x
• EISSN: 1097-6833
• ISSN: 0022-3476
• Language: English
• Keywords: Protein Binding; Antibodies, Monoclonal; Adult; Antigens, CD1; Immunoglobulin G; Histiocytosis, Langerhans-Cell; Autoantibodies; Indium Radioisotopes; Staining and Labeling; Child, Preschool; Humans; Injections, Intravenous; Immunoglobulin M; Mice; Fluorescent Antibody Technique; Animals; Child; Bone and Bones; Antigens, CD