Design and preclinical evaluation of a multigene human immunodeficiency virus type 1 subtype C DNA vaccine for clinical trial.

Journal article

In this study, the design and preclinical development of a multigene human immunodeficiency virus type 1 (HIV-1) subtype C DNA vaccine are described, developed as part of the South African AIDS Vaccine Initiative (SAAVI). Genetic variation remains a major obstacle in the development of an HIV-1 vaccine and recent strategies have focused on constructing vaccines based on the subtypes dominant in the developing world, where the epidemic is most severe. The vaccine, SAAVI DNA-C, contains an equi...

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Authors: Burgers, W; van Harmelen, J; Shephard, E; Adams, C; Mgwebi, T

• Publication status: Published
• Journal: Journal of general virology
• Volume: 87
• Issue: Pt 2
• Pages: 399-410
• Publication date: 2006-02-01
• DOI: 10.1099/vir.0.81379-0
• EISSN: 1465-2099
• ISSN: 0022-1317
• Language: English
• Keywords: Vaccines, DNA; Humans; Mice; Drug Evaluation, Preclinical; Drug Design; Animals; Genes, gag; AIDS Vaccines; HIV-1; Genes, env; Genes, tat