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An outer membrane receptor of Neisseria meningitidis involved in zinc acquisition with vaccine potential.

Abstract:

Since the concentration of free iron in the human host is low, efficient iron-acquisition mechanisms constitute important virulence factors for pathogenic bacteria. In Gram-negative bacteria, TonB-dependent outer membrane receptors are implicated in iron acquisition. It is far less clear how other metals that are also scarce in the human host are transported across the bacterial outer membrane. With the aim of identifying novel vaccine candidates, we characterized in this study a hitherto unk...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1000969

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Publisher:
Public Library of Science
Journal:
PLoS pathogens More from this journal
Volume:
6
Issue:
7
Pages:
e1000969
Publication date:
2010-01-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366

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