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A model invalidation-based approach for elucidating biological signalling pathways, applied to the chemotaxis pathway inR. sphaeroides

Abstract:

Background Developing methods for understanding the connectivity of signalling pathways is a major challenge in biological research. For this purpose, mathematical models are routinely developed based on experimental observations, which also allow the prediction of the system behaviour under different experimental conditions. Often, however, the same experimental data can be represented by several competing network models. Results In this paper, we developed a novel mathematical model/expe...

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M.A.J. Roberts More by this author
A. Hamadeh More by this author
P. K. Maini More by this author
P. E. McSharry More by this author
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Publication date:
2009
URN:
uuid:9ec4d1b0-12cb-4bd9-9ee0-3b61ca36ebc5
Local pid:
oai:eprints.maths.ox.ac.uk:852

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