Journal article
Preventing antibiotic-resistant infections: additively manufactured porous Ti6Al4V biofunctionalized with Ag and Fe nanoparticles
- Abstract:
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Implant-associated infections are highly challenging to treat, particularly with the emergence of multidrug-resistant microbials. Effective preventive action is desired to be at the implant site. Surface biofunctionalization of implants through Ag-doping has demonstrated potent antibacterial results. However, it may adversely affect bone regeneration at high doses. Benefiting from the potential synergistic effects, combining Ag with other antibacterial agents can substantially decrease the required Ag concentration. To date, no study has been performed on immobilizing both Ag and Fe nanoparticles (NPs) on the surface of additively manufactured porous titanium. We additively manufactured porous titanium and biofunctionalized its surface with plasma electrolytic oxidation using a Ca/P-based electrolyte containing Fe NPs, Ag NPs, and the combinations. The specimen’s surface morphology featured porous TiO2 bearing Ag and Fe NPs. During immersion, Ag and Fe ions were released for up to 28 days. Antibacterial assays against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa showed that the specimens containing Ag NPs and Ag/Fe NPs exhibit bactericidal activity. The Ag and Fe NPs worked synergistically, even when Ag was reduced by up to three times. The biofunctionalized scaffold reduced Ag and Fe NPs, improving preosteoblasts proliferation and Ca-sensing receptor activation. In conclusion, surface biofunctionalization of porous titanium with Ag and Fe NPs is a promising strategy to prevent implant-associated infections and allow bone regeneration and, therefore, should be developed for clinical application.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 4.2MB, Terms of use)
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- Publisher copy:
- 10.3390/ijms232113239
Authors
- Publisher:
- MDPI
- Journal:
- International Journal of Molecular Sciences More from this journal
- Volume:
- 23
- Issue:
- 21
- Article number:
- 13239
- Publication date:
- 2022-10-31
- Acceptance date:
- 2022-10-28
- DOI:
- EISSN:
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1422-0067
- ISSN:
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1661-6596
- Pmid:
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36362029
- Language:
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English
- Keywords:
- Pubs id:
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1300640
- Local pid:
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pubs:1300640
- Deposit date:
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2022-12-07
Terms of use
- Copyright holder:
- Putra et al.
- Copyright date:
- 2022
- Rights statement:
- © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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