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Decay-accelerating factor must bind both components of the complement alternative pathway C3 convertase to mediate efficient decay

Abstract:

Decay-accelerating factor (DAF; CD55) inhibits the complement (C) cascade by dissociating the multimolecular C3 convertase enzymes central to amplificatiom. We have previously demonstrated using surface plasmon resonance (Biacore International) that DAF mediates decay of the alternative pathway C3 convertase, C3bMb, but not of the inactive proenzyme, C3bB, and have shown that the major site of interaction is with the larger cleavage subunit factor B (Bb) subunit. In this study, we dissect the...

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Authors


Harris, CL More by this author
Pettigrew, DM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Morgan, BP More by this author
Journal:
Journal of Immunology
Volume:
178
Issue:
1
Pages:
352-359
Publication date:
2007
ISSN:
0022-1767
URN:
uuid:9eb72933-84bf-4e17-be48-7d5938034aba
Source identifiers:
148270
Local pid:
pubs:148270
Language:
English

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