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Journal article

Mathematical models of retinitis pigmentosa: The oxygen toxicity hypothesis

Abstract:

The group of genetically mediated diseases, known collectively as retinitis pigmentosa (RP), cause retinal degeneration and, hence, loss of vision. The most common inherited retinal degeneration, RP is currently untreatable. The retina detects light using cells known as photoreceptors, of which there are two types: rods and cones. In RP, genetic mutations cause patches of photoreceptors to degenerate and typically directly affect either rods or cones, but not both. During disease progression,...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.jtbi.2017.05.006

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Computer Science
More by this author
Institution:
University of Oxford
Department:
Brasenose College
Luthert, PJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Institute
Engineering and Physical Sciences Research Council More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Journal of Theoretical Biology Journal website
Volume:
425
Pages:
53-71
Publication date:
2017-05-06
Acceptance date:
2017-05-03
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
Pubs id:
pubs:692271
URN:
uri:9ea92b8d-a015-4c9e-804c-32e466533793
UUID:
uuid:9ea92b8d-a015-4c9e-804c-32e466533793
Local pid:
pubs:692271

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