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Effect of a tyrosine-free amino acid mixture on regional brain catecholamine synthesis and release.

Abstract:

We report the effects of a tyrosine (and phenylalanine)-free amino acid mixture on tyrosine levels, ex vivo catecholamine synthesis and in vivo catecholamine release in brain regions of the rat. Administration of a tyrosine-free amino acid load reduced tissue levels of tyrosine (-50% after 2 h) in all brain regions examined (frontal cortex, hippocampus, striatum). The tyrosine-free amino acid mixture also reduced DOPA accumulation: this effect was most marked in striatum (-44%) and nucleus ac...

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Publication status:
Published

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Publisher copy:
10.1007/s002130050823

Authors


McTavish, SF More by this author
Journal:
Psychopharmacology
Volume:
141
Issue:
2
Pages:
182-188
Publication date:
1999-01-05
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:9ea1356b-be5e-4bbe-aa01-529859dbb2ce
Source identifiers:
185876
Local pid:
pubs:185876

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