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Two monoclonal anti-human T lymphocyte antibodies have similar biologic effects and recognize the same cell surface antigen.

Abstract:

Two independently produced monoclonal antibodies, UCHT1, an IgG1 antibody, and OKT3, an IgG2 antibody, which specifically identify all human peripheral T lymphocytes, were shown to possess similar functional properties. Both were highly mitogenic to peripheral blood T lymphocytes, and UCHT1 blocked specific T lymphocyte killing of autologous B lymphoblasts when present during either the induction or the cytotoxic phase of the reaction; this, too, is a property reported for OKT3 in an analogou...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
129
Issue:
4
Pages:
1451-1457
Publication date:
1982-10-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:9e963a79-c20a-40d3-97de-99262984ee81
Source identifiers:
35556
Local pid:
pubs:35556

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