Non–genetic variation in phenotypes, or bet–hedging, has been observed as a driver of drug resistance in both bacterial infections and cancers. Here, we study how bet–hedging emerges in the genotype–phenotype mapping through a simple mechanistic model: a molecular switch. By using model Chemical Reaction Networks to implement a stochastic switch that maps gene products to phenotypes, we investigate the impact of structurally distinct mappings on the evolution of phenotypic heterogeneity. Bet–...Expand abstract
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