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Stochasticity in the genotype-phenotype map: Implications for the robustness and persistence of bet-hedging

Abstract:

Non–genetic variation in phenotypes, or bet–hedging, has been observed as a driver of drug resistance in both bacterial infections and cancers. Here, we study how bet–hedging emerges in the genotype–phenotype mapping through a simple mechanistic model: a molecular switch. By using model Chemical Reaction Networks to implement a stochastic switch that maps gene products to phenotypes, we investigate the impact of structurally distinct mappings on the evolution of phenotypic heterogeneity. Bet–...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1534/genetics.116.193474

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Department:
Oxford, MPLS, Computer Science
Robertson-Tessi, M More by this author
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Department:
Oxford, MPLS, Computer Science
Anderson, ARA More by this author
Publisher:
Genetics Society of America Publisher's website
Journal:
Genetics Journal website
Volume:
204
Issue:
4
Pages:
1523-1539
Publication date:
2016-10-20
Acceptance date:
2016-10-06
DOI:
ISSN:
0016-6766
Pubs id:
pubs:652693
URN:
uri:9e8f8788-8c86-4ff5-8d2e-c093d0d89821
UUID:
uuid:9e8f8788-8c86-4ff5-8d2e-c093d0d89821
Local pid:
pubs:652693

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