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Journal article

Control of heterologous hepatitis C virus infection in chimpanzees is associated with the quality of vaccine-induced peripheral T-helper immune response.

Abstract:

Prophylactic hepatitis C virus (HCV) vaccine trials with human volunteers are pending. There is an important need for immunological end points which correlate with vaccine efficacy and which do not involve invasive procedures, such as liver biopsies. By using a multicomponent DNA priming-protein boosting vaccine strategy, naïve chimpanzees were immunized against HCV structural proteins (core, E1, and E2) as well as a nonstructural (NS3) protein. Following immunization, exposure to the heterol...

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Publication status:
Published

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Authors


Rollier, C More by this author
Drexhage, JA More by this author
Verschoor, EJ More by this author
Verstrepen, BE More by this author
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Journal:
Journal of virology
Volume:
78
Issue:
1
Pages:
187-196
Publication date:
2004-01-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:9e88fb35-ceb4-4362-bfd0-b5534da438e7
Source identifiers:
111350
Local pid:
pubs:111350

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