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Journal article

Virological footprint of CD4+ T-cell responses during chronic hepatitis C virus infection.

Abstract:

Human and animal model evidence suggests that CD4+ T cells play a critical role in the control of chronic hepatitis C virus (HCV) infection. However, despite their importance, the mechanism behind the failure of such populations in chronic disease is not understood and the contribution of viral mutation is not known. To address this, this study defined the specificity and virological footprint of CD4+ T cells in chronic infection. CD8+ T-cell-depleted peripheral blood mononuclear cells from 6...

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Publication status:
Published

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Publisher copy:
10.1099/vir.0.017699-0

Authors


Fleming, VM More by this author
Harcourt, G More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Journal:
The Journal of general virology
Volume:
91
Issue:
Pt 6
Pages:
1396-1406
Publication date:
2010-06-05
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
URN:
uuid:9e820d7e-0ea5-425d-b17e-ff8d6f785585
Source identifiers:
46177
Local pid:
pubs:46177

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