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Journal article

Pathogen and host factors are needed to provoke a systemic host response to gastrointestinal infection of Drosophila larvae by Candida albicans.

Abstract:

Candida albicans systemic dissemination in immunocompromised patients is thought to develop from initial gastrointestinal (GI) colonisation. It is unclear what components of the innate immune system are necessary for preventing C. albicans dissemination from the GI tract, but studies in mice have indicated that both neutropenia and GI mucosal damage are crucial for allowing widespread invasive C. albicans disease. Mouse models, however, provide limited applicability to genome-wide screens for...

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Publication status:
Published

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Publisher copy:
10.1242/dmm.006627

Authors


Glittenberg, MT More by this author
Kounatidis, I More by this author
Christensen, D More by this author
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Journal:
Disease models and mechanisms
Volume:
4
Issue:
4
Pages:
515-525
Publication date:
2011-07-05
DOI:
EISSN:
1754-8411
ISSN:
1754-8403
URN:
uuid:9e749d26-b7ff-4d47-bd47-d7fb7a81a451
Source identifiers:
138816
Local pid:
pubs:138816

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