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Critical energies for SSB and DSB induction in plasmid DNA by low-energy photons: action spectra for strand-break induction in plasmid DNA irradiated in vacuum.

Abstract:

PURPOSE: To measure action spectra for the induction of single-strand breaks (SSB) and double-strand breaks (DSB) in plasmid DNA by low-energy photons and provide estimates for the energy dependence of strand-break formation important for track-structure simulations of DNA damage. MATERIALS AND METHODS: Plasmid pMSG-CAT was irradiated as a monolayer, under vacuum, with 7 150eV photons produced by a synchrotron source. Yields of SSB and DSB were determined by the separation of the three plasmi...

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Publication status:
Published

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Publisher copy:
10.1080/09553000050050891

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
International journal of radiation biology
Volume:
76
Issue:
7
Pages:
881-890
Publication date:
2000-07-01
DOI:
EISSN:
1362-3095
ISSN:
0955-3002
Source identifiers:
131087
Language:
English
Keywords:
Pubs id:
pubs:131087
UUID:
uuid:9e6be1f0-ee4e-45c4-b6df-318cb8dca7da
Local pid:
pubs:131087
Deposit date:
2013-11-16

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