Although plasma leakage is the hallmark of severe dengue infections, the factors that cause increased vascular permeability have not been identified. As platelet activating factor (PAF) is associated with an increase in vascular permeability in other diseases, we set out to investigate its role in acute dengue infection.
Materials and Methods
PAF levels were initially assessed in 25 patients with acute dengue infection to determine if they were increased...Expand abstract
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- Peer reviewed
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- Public Library of Science Publisher's website
- PLoS Neglected Tropical Diseases Journal website
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- ARTN e0003459
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- Jeewandara et al
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- © 2015 Jeewandara et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Platelet activating factor contributes to vascular leak in acute dengue infection.
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