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Insulin-like growth factor i and risk of breast cancer by age and hormone receptor status - A prospective study within the EPIC cohort

Abstract:

Experimental evidence shows cross-talk in mammary cells between estrogen, insulin-like growth factor I (IGF-I) and their respective receptors and possible synergistic effects of estrogen receptor (ER) activation and increased IGF-I signaling with regard to breast tumor development, and epidemiological evidence suggests that circulating IGF-I levels may be related more to the risk of ER-positive than ER-negative breast cancer. Using a case-control study nested within the prospective European E...

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Publisher copy:
10.1002/ijc.28589

Authors


Johnson, T More by this author
Sookthai, D More by this author
Tjønneland, A More by this author
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Publisher:
Wiley-Liss Inc.
Journal:
International Journal of Cancer
Volume:
134
Issue:
11
Pages:
2683-2690
Publication date:
2014-06-01
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
URN:
uuid:9e61ce78-7dce-4d70-be5b-74777c89316c
Source identifiers:
458676
Local pid:
pubs:458676

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