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Perinatal glucocorticoid treatment disrupts the hypothalamo-lactotroph axis in adult female, but not male, rats.

Abstract:

This study aimed to test the hypothesis that the tuberoinfundibular dopaminergic neurons of the arcuate nucleus and/or the lactotroph cells of the anterior pituitary gland are key targets for the programming effects of perinatal glucocorticoids (GCs). Dexamethasone was administered noninvasively to fetal or neonatal rats via the mothers' drinking water (1 mug/ml) on embryonic d 16-19 or neonatal d 1-7, and control animals received normal drinking water. At 68 d of age, the numbers of tyrosine...

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Publication status:
Published

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Publisher copy:
10.1210/en.2005-1496

Authors


McArthur, S More by this author
Siddique, ZL More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Theogaraj, E More by this author
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Journal:
Endocrinology
Volume:
147
Issue:
4
Pages:
1904-1915
Publication date:
2006-04-05
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
URN:
uuid:9e59fdc4-b9eb-4222-bfb2-6c0ec3de35d5
Source identifiers:
114669
Local pid:
pubs:114669

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