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Structural and functional dissection of a conserved destabilizing element of cyclo-oxygenase-2 mRNA: evidence against the involvement of AUF-1 [AU-rich element/poly(U)-binding/degradation factor-1], AUF-2, tristetraprolin, HuR (Hu antigen R) or FBP1 (far-upstream-sequence-element-binding protein 1).

Abstract:

COX-2 (cyclo-oxygenase-2) mRNA is degraded rapidly in resting cells, but is stabilized by the mitogen-activated protein kinase p38 signalling pathway in response to pro-inflammatory stimuli. A conserved ARE (AU-rich element) of the COX-2 3' untranslated region, CR1 (conserved region 1), acts as a potent instability determinant, and mediates stabilization in response to p38 activation. A detailed structural and functional analysis of this element was performed in an attempt to identify RNA-bin...

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Publication status:
Published

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Publisher copy:
10.1042/BJ20031484

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Rawlinson, L More by this author
Santalucia, T More by this author
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Journal:
The Biochemical journal
Volume:
377
Issue:
Pt 3
Pages:
629-639
Publication date:
2004-02-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:9e596534-b0d2-4d76-be97-41a202ec2a62
Source identifiers:
226082
Local pid:
pubs:226082

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